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91.
Constantin Tnase Lucia Pintilie Raluca Elena Tnase 《International journal of molecular sciences》2021,22(4)
In the total stereo-controlled synthesis of natural prostaglandins (PGs) and their structural analogs, a vast class of compounds and drugs, known as the lactones, are encountered in a few key steps to build the final molecule, as: δ-lactones, γ-lactones, and 1,9-, 1,11-, and 1,15-macrolactones. After the synthesis of 1,9-PGF2α and 1,15-PGF2α lactones, many 1,15-lactones of E2, E3, F2, F3, A2, and A3 were found in the marine mollusc Tethys fimbria and the quest for understanding their biological role stimulated the research on their synthesis. Then 1,9-, 1,11-, and 1,15-PG lactones of the drugs were synthesized as an alternative to the corresponding esters, and the first part of the paper describes the methods used for their synthesis. The efficient Corey procedure for the synthesis of prostaglandins uses the key δ-lactone and γ-lactone intermediates with three or four stereocenters on the cyclopentane fragment to link the PG side chains. The paper describes the most used procedures for the synthesis of the milestone δ-Corey-lactones and γ-Corey-lactones, their improvements, and some new promising methods, such as interesting, new stereo-controlled and catalyzed enantioselective reactions, and methods based on the chemical/enzymatic resolution of the compounds in different steps of the sequences. The many uses of δ-lactones not only for the synthesis of γ-lactones, but also for obtaining 9β-halogen-PGs and halogen-substituted cyclopentane intermediates, as synthons for new 9β-PG analogs and future applications, are also discussed. 相似文献
92.
Joana Silva Celso Alves Alice Martins Patrícia Susano Marco Simes Miguel Guedes Stephanie Rehfeldt Susete Pinteus Helena Gaspar Amrico Rodrigues Mrcia Ines Goettert Amparo Alfonso Rui Pedrosa 《International journal of molecular sciences》2021,22(4)
Parkinsons Disease (PD) is the second most common neurodegenerative disease worldwide, and is characterized by a progressive degeneration of dopaminergic neurons. Without an effective treatment, it is crucial to find new therapeutic options to fight the neurodegenerative process, which may arise from marine resources. Accordingly, the goal of the present work was to evaluate the ability of the monoterpenoid lactone Loliolide, isolated from the green seaweed Codium tomentosum, to prevent neurological cell death mediated by the neurotoxin 6-hydroxydopamine (6-OHDA) on SH-SY5Y cells and their anti-inflammatory effects in RAW 264.7 macrophages. Loliolide was obtained from the diethyl ether extract, purified through column chromatography and identified by NMR spectroscopy. The neuroprotective effects were evaluated by the MTT method. Cells’ exposure to 6-OHDA in the presence of Loliolide led to an increase of cells’ viability in 40%, and this effect was mediated by mitochondrial protection, reduction of oxidative stress condition and apoptosis, and inhibition of the NF-kB pathway. Additionally, Loliolide also suppressed nitric oxide production and inhibited the production of TNF-α and IL-6 pro-inflammatory cytokines. The results suggest that Loliolide can inspire the development of new neuroprotective therapeutic agents and thus, more detailed studies should be considered to validate its pharmacological potential. 相似文献
93.
Seulah Lee Yeon Ji Suh Seonguk Yang Dong Geun Hong Akihito Ishigami Hangun Kim Jae-Seoun Hur Seung-Cheol Chang Jaewon Lee 《International journal of molecular sciences》2021,22(4)
Oxidative stress, mitochondrial dysfunction, and neuroinflammation are strongly associated with the pathogenesis of Parkinson’s disease (PD), which suggests that anti-oxidative and anti-inflammatory compounds might provide an alternative treatment for PD. Here, we evaluated the neuroprotective effects of evernic aid (EA), which was screened from a lichen library provided by the Korean Lichen Research Institute at Sunchon National University. EA is a secondary metabolite generated by lichens, including Ramalina, Evernia, and Hypogymnia, and several studies have described its anticancer, antifungal, and antimicrobial effects. However, the neuroprotective effects of EA have not been studied. We found that EA protected primary cultured neurons against 1-methyl-4-phenylpyridium (MPP+)-induced cell death, mitochondrial dysfunction, and oxidative stress, and effectively reduced MPP+-induced astroglial activation by inhibiting the NF-κB pathway. In vivo, EA ameliorated MPTP-induced motor dysfunction, dopaminergic neuronal loss, and neuroinflammation in the nigrostriatal pathway in C57BL/6 mice. Taken together, our findings demonstrate that EA has neuroprotective and anti-inflammatory effects in PD models and suggest that EA is a potential therapeutic candidate for PD. 相似文献
94.
Saerom Lee Ga-Eun Lim Yong-Nyun Kim Hyeon-Sook Koo Jaegal Shim 《International journal of molecular sciences》2021,22(4)
The extracellular matrix (ECM) is important for normal development and disease states, including inflammation and fibrosis. To understand the complex regulation of ECM, we performed a suppressor screening using Caenorhabditis elegans expressing the mutant ROL-6 collagen protein. One cuticle mutant has a mutation in dpy-23 that encodes the μ2 adaptin (AP2M1) of clathrin-associated protein complex II (AP-2). The subsequent suppressor screening for dpy-23 revealed the lon-2 mutation. LON-2 functions to regulate body size through negative regulation of the tumor growth factor-beta (TGF-β) signaling pathway responsible for ECM production. RNA-seq analysis showed a dominant change in the expression of collagen genes and cuticle components. We noted an increase in the cav-1 gene encoding caveolin-1, which functions in clathrin-independent endocytosis. By knockdown of cav-1, the reduced TGF-β signal was significantly restored in the dpy-23 mutant. In conclusion, the dpy-23 mutation upregulated cav-1 expression in the hypodermis, and increased CAV-1 resulted in a decrease of TβRI. Finally, the reduction of collagen expression including rol-6 by the reduced TGF-β signal influenced the cuticle formation of the dpy-23 mutant. These findings could help us to understand the complex process of ECM regulation in organism development and disease conditions. 相似文献
95.
光降解乙醛(CH3CHO)是一种新型高效的乙醛去除方法,通常采用TiO2作为光催化剂。然而TiO2对乙醛吸附能力较弱,对产物的选择性较低,电子-空穴对重组率较高,严重限制了对乙醛的降解性能。本研究通过在TiO2上负载CuAg纳米粒子(CuAg/TiO2),成功构建了高效稳定的光催化降解乙醛催化剂,有效解决了TiO2的固有缺陷。在自然光照射下,CuAg/TiO2对乙醛的降解率高达42.49%。连续4轮全光谱光催化降解乙醛,CuAg/TiO2活性均保持在98.89%以上。进一步的机理研究表明,CuAg/TiO2中的CuAg纳米粒子在光照下产生热电子,随后热电子转移到TiO2和吸附在Ag位点上的氧中。CuAg/TiO2上生成的超氧自由基能有效地降解乙醛,从而在乙醛降解过程中表现出优异的性能。 相似文献
96.
协同过滤算法(CF)根据用户-物品的评分矩阵做推荐,未考虑物品自身属性。本文将MovieLens数据集上的电影属性,作为影响推荐结果的因素,融合电影的简介、评论、评分、导演和演员等多种因素,进行推荐。使用CNN(卷积神经网络)和Word2Vec(Word to Vector,词向量模型)处理电影简介;使用AFINN(Finn rup Nielsen情感词典)处理评论,并对结果进行映射;对导演和演员数据进行建模,得到该因素下的预测评分,最后将各因素下的结果进行加权融合,通过调整权重,得到最佳效果。经验证,该方法的推荐性能优于传统的CF算法。 相似文献
97.
98.
以甲基丙烯酸十二氟庚酯(DFHMA)和甲基丙烯酸(MAA)为单体,通过溶液聚合法制备出共聚物DFHMA-co-MAA,将DFHMA-co-MAA与聚偏氟乙烯(PVDF)按一定质量共混,采用静电纺丝方法,制备出羧基含氟聚合物(PVDF-DM)纳米纤维膜,用以吸附溶液中Cu(II)。讨论了PVDF和DFHMA-co-MAA的质量配比对纤维微观形貌和对Cu(II)吸附性能的影响,得出当PVDF与DFHMA-co-MAA的质量比为1∶2时,纤维的微观直径较均一且吸附性能最佳,故实验采用该质量配比制备PVDF-DM。使用红外光谱对PVDF-DM进行表征,显示出PVDF-DM纤维膜中含有—OH和C=O等活性吸附基团。以PVDF-DM纳米纤维膜为吸附剂,探讨了吸附剂用量、吸附pH值和吸附时间对Cu(II)吸附性能的影响,并研究了吸附过程的动力学模型。结果表明,室温下,当吸附剂用量为0.03g,pH=5时,吸附60min达到吸附平衡,吸附率和吸附量分别为94.37%和62.91mg/g,PVDF-DM纳米纤维膜对Cu(II)的吸附过程同时满足拟一级动力学和拟二级动力学模型,说明该吸附过程包含了化学吸附和物理吸附。PVDF-DM纳米纤维膜循环使用5次后,吸附能力仅降低16.23%,说明PVDF-DM纳米纤维膜具有很好的再生使用能力。 相似文献
99.
Thiamine Deficiency Complex (TDC) is an ongoing problem impacting salmonine health in various waterbodies, including Lake Ontario. The prevalence of TDC has been variable and explanations for differences are limited. In the current study, thiamine concentrations were measured in eggs, liver tissue, and muscle tissue sampled from brown trout (Salmo trutta), Chinook salmon (Oncorhynchus tshawytscha), coho salmon (O. kisutch), lake trout (Salvelinus namaycush), and steelhead trout (O. mykiss) that were collected from Lake Ontario and its surrounding tributaries. The occurrence of TDC was measured for each species based on TDC-induced offspring mortality rates under laboratory conditions. TDC-induced offspring mortality was observed for all species except brown trout. For affected species, egg free thiamine (Th) was consistently low compared to lake trout collected from Lake Superior that are considered thiamine replete. In addition, species with the lowest percentages of Th in their eggs were the most susceptible to TDC, suggesting that limited thiamine reserves in the form of Th may cause TDC-induced offspring mortality. Lastly, our results show that egg thiamine concentrations have yearly variation and increased for all species throughout the study. Reasons for such variation are undetermined; but, if egg thiamine concentrations continue to increase, the impacts of TDC on these salmonine species may lessen. Future monitoring is needed for determining if thiamine concentrations are increasing and the potential impacts that may have on the entire Lake Ontario fishery. 相似文献
100.